Noise exposure-related central auditory changes (Bramhall et al., 2020)
journal contributionposted on 17.03.2020, 16:51 authored by Naomi F. Bramhall, Christopher E. Niemczak, Sean D. Kampel, Curtis J. Billings, Garnett P. McMillan
Purpose: Complaints of auditory perceptual deficits, such as tinnitus and difficulty understanding speech in background noise, among individuals with clinically normal audiograms present a perplexing problem for audiologists. One potential explanation for these “hidden” auditory deficits is loss of the synaptic connections between the inner hair cells and their afferent auditory nerve fiber targets, a condition that has been termed cochlear synaptopathy. In animal models, cochlear synaptopathy can occur due to aging or exposure to noise or ototoxic drugs and is associated with reduced auditory brainstem response (ABR) wave I amplitudes. Decreased ABR wave I amplitudes have been demonstrated among young military Veterans and non-Veterans with a history of firearm use, suggesting that humans may also experience noise-induced synaptopathy. However, the downstream consequences of synaptopathy are unclear.
Method: To investigate how noise-induced reductions in wave I amplitude impact the central auditory system, the ABR, the middle latency response (MLR), and the late latency response (LLR) were measured in 65 young Veterans and non-Veterans with normal audiograms.
Results: In response to a click stimulus, the MLR was weaker for Veterans compared to non-Veterans, but the LLR was not reduced. In addition, low ABR wave I amplitudes were associated with a reduced MLR, but with an increased LLR. Notably, Veterans reporting tinnitus showed the largest mean LLRs.
Conclusions: These findings indicate that decreased peripheral auditory input leads to compensatory gain in the central auditory system, even among individuals with normal audiograms, and may impact auditory perception. This pattern of reduced MLR, but not LLR, was observed among Veterans even after statistical adjustment for sex and distortion product otoacoustic emission differences, suggesting that synaptic loss plays a role in the observed central gain.
Supplemental Material S1. Description of priors for Bayesian regression model.
Bramhall, N. F., Niemczak, C. E., Kampel, S. D., Billings, C. J., & McMillan, G. P. (2020). Evoked potentials reveal noise exposure–related central auditory changes despite normal audiograms. American Journal of Audiology. Advance online publication. https://doi.org/10.1044/2019_AJA-19-00060
This work was supported by the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service Awards C2104-W (awarded to N. F. B.) and C9230-C (awarded to the National Center for Rehabilitative Auditory Research) and by National Institute on Deafness and Other Communication Disorders Grant R01DC015240 (awarded to C. J. B.). Research audiologist support was also provided by the Department of Defense Hearing Center of Excellence and zCore Business Solutions, Inc.
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