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PPA diagnosis (Europa et al., 2020)

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posted on 10.09.2020 by Eduardo Europa, Leonardo Iaccarino, David C. Perry, Elizabeth Weis, Ariane E. Welch, Gil D. Rabinovici, Bruce L. Miller, Maria Luisa Gorno-Tempini, Maya L. Henry
Purpose: Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the-art procedures that may improve diagnostic precision.
Method: We describe the diagnostic evaluation of a 49-year-old woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis.
Conclusion: Detailed behavioral assessment, thorough intake of symptom history and neurodevelopmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention.

Supplemental Material S1. Supplemental methods.

Europa, E., Iaccarino, L., Perry, D. C., Weis, E., Welch, A. E., Rabinovici, G. D., Miller, B. L., Gorno-Tempini, M. L., & Henry, M. L. (2020). Diagnostic assessment in primary progressive aphasia: An illustrative case example. American Journal of Speech-Language Pathology. Advance online publication. https://doi.org/10.1044/2020_AJSLP-20-00007

Funding

This work was supported by P01AG019724 and P30AG062422 from the National Institute on Aging awarded to Bruce L. Miller, R01DC016291 from the National Institute on Deafness and Other Communication Disorders awarded to Maya L. Henry, and R01NS05091 from the National Institute of Neurological Disorders and Stroke and K24DC015544 from the National Institute on Deafness and Other Communication Disorders awarded toMaria Luisa Gorno-Tempini.

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