ILAT induced recruitment of domain general systems (Dreyer et al., 2020)
journal contributionposted on 2020-08-24, 15:27 authored by Felix R. Dreyer, Lea Doppelbauer, Verena Büscher, Verena Arndt, Benjamin Stahl, Guglielmo Lucchese, Olaf Hauk, Bettina Mohr, Friedemann Pulvermüller
Purpose: This study aimed to provide novel insights into the neural correlates of language improvement following intensive language-action therapy (ILAT; also known as constraint-induced aphasia therapy).
Method: Sixteen people with chronic aphasia underwent clinical aphasia assessment (Aachen Aphasia Test [AAT]), as well as functional magnetic resonance imaging (fMRI), both administered before (T1) and after ILAT (T2). The fMRI task included passive reading of single written words, with hashmark strings as visual baseline.
Results: Behavioral results indicated significant improvements of AAT scores across therapy, and fMRI results showed T2–T1 blood oxygenation-level-dependent (BOLD) signal change in the left precuneus to be modulated by the degree of AAT score increase. Subsequent region-of-interest analysis of this precuneus cluster confirmed a positive correlation of T2–T1 BOLD signal change and improvement on the clinical aphasia test. Similarly, the entire default mode network revealed a positive correlation between T2–T1 BOLD signal change and clinical language improvement.
Conclusion: These results are consistent with a more efficient recruitment of domain-general neural networks in language processing, including those involved in attentional control, following aphasia therapy with ILAT.
Supplemental Material S1. Supplemental figures and tables.
Dreyer, F. R., Doppelbauer, L., Büscher, V., Arndt, V., Stahl, B., Lucchese, G., Hauk, O., Mohr, B., & Pulvermüller, F. (2020). Increased recruitment of domain-general neural networks in language processing following intensive language-action therapy: fMRI evidence from people with chronic aphasia. American Journal of Speech-Language Pathology. Advance online publication. https://doi.org/10.1044/2020_AJSLP-19-00150
Publisher Note: This article is part of the Special Issue: Select Papers From the 49th Clinical Aphasiology Conference.
This work was supported by the Deutsche Forschungsgemeinschaft (pu 97/15-1 and 97/15-2 awarded to F. P.), the Deutsche Akademische Austauschdienst (fellowship to G. L.), and the Einstein Center for Neuroscience Berlin (fellowship awarded to L. D.).
languageaphasianeuralneurologynetworksprocessingtherapyfMRIchronic aphasiadomaingeneralrecruitmentinsightintensiveintensive language-action therapyILATconstraint-induced aphasia therapyassessmentclinicalAachen Aphasia Testreadingpassivewrittenwordsvisualbehavioralbloodoxygenationblood oxygenation-level-dependentBOLDprecuneusregion-of-interestmodeimprovementefficientattentioncontrolLanguageNeurology and Neuromuscular Diseases