ASHA journals
PERSP-20-00283Iuzzini-Seigel_SuppS1.pdf (683.94 kB)

Communication and motor abilities in CAS (Iuzzini-Seigel et al., 2022)

Download (683.94 kB)
journal contribution
posted on 2022-01-27, 22:12 authored by Jenya Iuzzini-Seigel, Amy L. Delaney, Ray D. Kent
Purpose: This study sought to determine if children with childhood apraxia of speech (CAS) plus another major diagnosis (CAS+) are equivalent in communication and motor profiles to those with a primary diagnosis of CAS and no indication or report of any other diagnosis (CAS-Primary).
Method: This retrospective case–control study included a chart review of 143 children who were suspected of having CAS at Children’s Hospital-Wisconsin between 1998 and 2004. Participants were between 30 and 127 months old and included 107 males. Participants were assigned to the suspected CAS-Primary group (n = 114) if they had characteristics of CAS but no other major diagnosis (e.g., galactosemia) and to the CAS+ group (n = 29) if a comorbid diagnosis was present. Groups were compared across demographic, communication, and motor characteristics.
Results: Children with CAS+ evidenced more severe motor profiles than those with CAS-Primary, χ2 = (1, n = 122) = 4.952, p = .026, and a small-to-medium effect size (Ф = .201). On average, communication profiles also tended to be more severe among those with CAS+ wherein receptive language was poorer and phonemic inventories were smaller than those with CAS-Primary.
Conclusions: These retrospective data suggest that comorbid diagnosis may play an important role in communication and motor development in children with suspected CAS. These exploratory findings should motivate future prospective studies that consider the role of concomitant diagnoses in symptom profile and response to treatment in children with CAS.

Supplemental Material S1. CAS in special populations. The capsule descriptions below highlight select populations in which CAS has been reported. Here we describe communication and motor deficits evidenced by some of the complex genetic, metabolic, and neurobehavioral populations that have been previously associated with CAS. The occurrence of CAS in different disorder groups may hold clues regarding its nature and origin.

Iuzzini-Seigel, J., Delaney, A. L., & Kent, R. D. (2022). Retrospective case–control study of communication and motor abilities in 143 children with suspected childhood apraxia of speech: Effect of concomitant diagnosis. Perspectives of the ASHA Special Interest Groups. Advance online publication.


Funding was provided by Marquette University’s Summer Faculty Fellowship and Regular Research Grant (PI: Iuzzini-Seigel) and National Institutes of Health National Institute on Deafness and Other Communication Disorders T32 DC05359 (PIs: Kent and Ellis-Weismer).