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Acoustic biomarkers in Huntington’s disease (Fahed et al., 2024)

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posted on 2024-03-26, 16:08 authored by Vitória S. Fahed, Emer P. Doheny, Carla Collazo, Joanna Krzysztofik, Elliot Mann, Philippa Morgan-Jones, Laura Mills, Cheney Drew, Anne E. Rosser, Rebecca Cousins, Grzegorz Witkowski, Esther Cubo, Monica Busse, Madeleine M. Lowery

Purpose: Changes in voice and speech are characteristic symptoms of Huntington’s disease (HD). Objective methods for quantifying speech impairment that can be used across languages could facilitate assessment of disease progression and intervention strategies. The aim of this study was to analyze acoustic features to identify language-independent features that could be used to quantify speech dysfunction in English-, Spanish-, and Polish-speaking participants with HD.

Method: Ninety participants with HD and 83 control participants performed sustained vowel, syllable repetition, and reading passage tasks recorded with previously validated methods using mobile devices. Language-independent features that differed between HD and controls were identified. Principal component analysis (PCA) and unsupervised clustering were applied to the language-independent features of the HD data set to identify subgroups within the HD data.

Results: Forty-six language-independent acoustic features that were significantly different between control participants and participants with HD were identified. Following dimensionality reduction using PCA, four speech clusters were identified in the HD data set. Unified Huntington’s Disease Rating Scale (UHDRS) total motor score, total functional capacity, and composite UHDRS were significantly different for pairwise comparisons of subgroups. The percentage of HD participants with higher dysarthria score and disease stage also increased across clusters.

Conclusion: The results support the application of acoustic features to objectively quantify speech impairment and disease severity in HD in multilanguage studies.

Supplemental Material S1. Experimental setup for speech recording using mobile devices.

Fahed, V. S., Doheny, E. P., Collazo, C., Krzysztofik, J., Mann, E., Morgan-Jones, P., Mills, L., Drew, C., Rosser, A. E., Cousins, R., Witkowski, G., Cubo, E., Busse, M., & Lowery, M. M. (2024). Language-independent acoustic biomarkers for quantifying speech impairment in Huntington’s disease. American Journal of Speech-Language Pathology, 33(3), 1390–1405.


Multi-Domain Lifestyle Targets for Improving Prognosis in Huntington’s disease (DOMINO-HD) is funded through the EU Joint Program for Neurodegenerative Disease Research (JPND) as part of the JPND funding call in to Health and Social Care (2019) with funding from Alzheimer’s Society, Secretary of State for Health and Social Care, Health and Care Research Wales, Public Health Agency Northern Ireland, Jacques and Gloria Gossweiler Foundation, Bundesministerium für Bildung und Forschung, Narodowe Centrum Badań i Rozwoju, Swiss National Science Foundation (32ND30_185548), and Health Research Board (JPND-HSC-2018-003), awarded to Monica Busse, Madeleine Lowery, Grzegorz Witkowski, and Esther Cubo.