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Computer-based treatment for svPPA (Robinaugh et al., 2024)

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posted on 2024-02-06, 16:16 authored by Gary Robinaugh, Maya L. Henry, Robert Cavanaugh, Stephanie M. Grasso

Purpose: The purpose of this study was to investigate the effectiveness of a self-administered naming treatment for one individual, B.N., presenting with semantic variant primary progressive aphasia (svPPA) and a history of traumatic brain injury (TBI).

Method: Naming treatment included components of Lexical Retrieval Cascade Treatment and was self-administered using an adaptive spaced retrieval software, Anki. Using a multiple-baseline, single-case experimental design, naming accuracy probes were taken during pretreatment, treatment, posttreatment, and follow-up (through 12 months) for 60 trained words and 10 untrained words. Item-level Bayesian generalized mixed-effects models were used to estimate (a) the treatment effect for trained words, (b) change in untrained words, and (c) maintenance of treatment effects from posttreatment to each subsequent follow-up.

Results: Statistical analyses revealed that a gain of 35 out of 60 trained words (35.3; 90% CI [30.6, 39.5]) was directly attributable to treatment. Following treatment, evidence of generalization to untrained words was not observed. During the follow-up period, there was gradual decline in naming accuracy of trained items.

Conclusions: The positive treatment results reported here support the use of self-administered naming treatments for those with svPPA and a history of TBI. Although the utility of this treatment approach is constrained by patient factors including motivation, self-administered naming treatments represent a unique opportunity to expand access to speech-language intervention for people with svPPA, including those with concomitant diagnoses.

Supplemental Material S1. R code and summary of population-level and group-level effects.

Supplemental Material S2. Sensitivity analysis.

Robinaugh, G., Henry, M. L., Cavanaugh, R., & Grasso, S. M. (2024). Computer‐based naming treatment for semantic variant primary progressive aphasia with history of traumatic brain injury: A single‐case experimental design. Journal of Speech, Language, and Hearing Research, 67(2), 524–544.‐23‐00289


Research reported in this article was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under Grant R01 DC016291 (awarded to principal investigator: Maya Henry).