Swallowing physiology in Parkinson disease (Gandhi et al., 2021)
datasetposted on 2021-07-27, 20:34 authored by Pooja Gandhi, Renata Mancopes, Danielle Sutton, Emily K. Plowman, Catriona M. Steele
Purpose: Dysphagia is thought to be prevalent and a leading cause of morbidity and mortality in people with Parkinson disease (PwPD). The aim of this study was to compare the frequencies of atypical and extreme values for measures of swallowing physiology in PwPD and in an age- and sex-matched cohort of healthy adults. Atypical and extreme values were defined, respectively, as values falling in the 25% and 5% tails of the reference distribution for healthy adults under age 60 years.
Method: A standard videofluoroscopy (VF) protocol was performed in 17 adults with mild PD and 17 age- and sex-matched healthy adults using 20% w/v liquid barium ranging from thin to extremely thick consistency. Blinded VF analysis was performed according to the Analysis of Swallowing Physiology: Events, Kinematics and Timing Method. Frequencies for atypical and extreme values were tabulated by cohort and compared using odds ratios.
Results: Increased frequencies of atypical values (> 25%) were seen in the PwPD for prolonged swallow reaction time, prolonged time-to-laryngeal-vestibule-closure (LVC), and poor pharyngeal constriction. However, these findings were also observed in the healthy controls. The PwPD showed significantly higher odds of atypical values for narrow upper esophageal sphincter (UES) diameter on thin liquids, a short hyoid-burst-to-UES-opening interval on extremely thick liquids, and prolonged time-to-LVC, LVC duration, and UES opening duration on multiple consistencies. The frequencies of extreme values failed to show any significant cohort differences for any parameter.
Conclusions: In this study, a group of people with mild PD did not show clear evidence of swallowing impairments distinct from the changes seen in a healthy age-matched control group when odds ratios were used to compare the frequencies of atypical values between PwPD and the control group; only a few parameters showed significant differences. These were findings of significantly higher frequencies in PwPD of prolonged LVC and UES opening duration.
Supplemental Material S1. This supplement contains descriptive statistics for measures of swallowing based on duplicated blinded review of videofluoroscopies, performed according to the ASPEKT Method.
Gandhi, P., Mancopes, R., Sutton, D., Plowman, E. K., & Steele, C. M. (2021). The frequency of atypical and extreme values for pharyngeal phase swallowing measures in mild Parkinson disease compared to healthy aging. Journal of Speech, Language, and Hearing Research. Advance online publication. https://doi.org/10.1044/2021_JSLHR-21-00084
Funding for this study was provided through an RO1 grant from the National Institute on Deafness and Other Communication Disorders (R01 DC011020) to the last author.
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Parkinson diseaseswallowingswallowpharyngeal phasedysphagiafrequencyatypicalextremevaluesmeasuresphysiologyvideofluoroscopymatchedadultsbariumthinthickconsistencyAnalysis of Swallowing Physiology: Events, Kinematics and Timing MethodASPEKT Methodliquidreaction timelaryngeal vestibule closureLVCpharyngeal constrictionupper esophageal sphincterUEShyoid burstdurationimpairmentNeurology and Neuromuscular DiseasesPhysiology