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Long-term averaged spectrum in Parkinson’s disease (Svihlik et al., 2022)

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posted on 2022-12-06, 17:33 authored by Jan Svihlik, Michal Novotny, Tereza Tykalova, Kamila Polakova, Hana Brozova, Petr Kryze, Mario Sousa, Paul Krack, Elina Tripoliti, Evzen Ruzicka, Robert Jech, Jan Rusz

Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson’s disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech.

Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age- and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions.

Results: All LTAS spectral moments including mean, standard deviation, skewness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p < .05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups.

Conclusions: Our findings confirmed that LTAS is a suitable approach to objectively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria.

Supplemental Material S1. Clinical characteristics of patients with Parkinson’s disease treated with subthalamic nucleus deep brain stimulation. 

Svihlik, J., Novotny, M., Tykalova, T., Polakova, K., Brozova, H., Kryze, P., Sousa, M., Krack, P., Tripoliti, E., Ruzicka, E., Jech, R., & Rusz, J. (2022). Long-term averaged spectrum descriptors of dysarthria in patients with Parkinson’s disease treated with subthalamic nucleus deep brain stimulation. Journal of Speech, Language, and Hearing Research. Advance online publication. https://doi.org/10.1044/2022_JSLHR-22-00308

Funding

This study was supported by the Czech Science Foundation (Grant 21-14216 L awarded to J. Svihlik, P. Kryze, M. Sousa, P. Krack, R. Jech, and J. Rusz), the Czech Ministry of Health (Grant NV19-04-00233 awarded to R. Jech and MH CZ–DRO-VFN64165 awarded to E. Ruzicka, R. Jech, and J. Rusz), and the Czech Ministry of Education: National Institute for Neurological Research (Programme EXCELES; ID Project LX22NPO5107 awarded to M. Novotny, T. Tykalova, E. Ruzicka, R. Jech, and J. Rusz), funded by the European Union – NextGenerationEU.

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