10.23641/asha.5899228.v1
Thea Knowles
Thea
Knowles
Scott Adams
Scott
Adams
Anita Abeyesekera
Anita
Abeyesekera
Cynthia Mancinelli
Cynthia
Mancinelli
Greydon Gilmore
Greydon
Gilmore
Mandar Jog
Mandar
Jog
STN-DBS parameter optimization for speech in PD (Knowles et al., 2018)
ASHA journals
2018
speech
Parkinson's
Parkinson's disease
deep brain stimulation
subthalamic nucleus
acoustics
vowel
intelligibility
parameters
optimization
vowel production
gender
sex
frequency
voltage
pulse width
speech outcomes
STN-DBS
neurodegenerative
movement disorder
hypokinetic
dysarthria
Linguistic Processes (incl. Speech Production and Comprehension)
Neurology and Neuromuscular Diseases
2018-02-22 20:53:15
Dataset
https://asha.figshare.com/articles/dataset/STN-DBS_parameter_optimization_for_speech_in_PD_Knowles_et_al_2018_/5899228
<div><b>Purpose:</b> The settings of 3 electrical stimulation parameters were adjusted in 12 speakers with Parkinson’s disease (PD) with deep brain stimulation of the subthalamic nucleus (STN-DBS) to examine their effects on vowel acoustics and speech intelligibility.</div><div><b>Method: </b>Participants were tested under permutations of low, mid, and high STN-DBS frequency, voltage, and pulse width settings. At each session, participants recited a sentence. Acoustic characteristics of vowel production were extracted, and naive listeners provided estimates of speech intelligibility.</div><div><b>Results:</b> Overall, lower-frequency STN-DBS stimulation (60 Hz) was found to lead to improvements in intelligibility and acoustic vowel expansion. An interaction between speaker sex and STN-DBS stimulation was found for vowel measures. The combination of low frequency, mid to high voltage, and low to mid pulse width led to optimal speech outcomes; however, these settings did not demonstrate significant speech outcome differences compared with the standard clinical STN-DBS settings, likely due to substantial individual variability.</div><div><b>Conclusions: </b>Although lower-frequency STN-DBS stimulation was found to yield consistent improvements in speech outcomes, it was not found to necessarily lead to the best speech outcomes for all participants. Nevertheless, frequency may serve as a starting point to explore settings that will optimize an individual’s speech outcomes following STN-DBS surgery.</div><div><br></div><div><b>Supplemental Material S1. </b>Estimated pairwise differences for speech intelligibility (%) from the final model.</div><div><b><br></b></div><div><b>Supplemental Material S2. </b>Estimated pairwise differences for four-vowel articulation index (VAI) from the final model.</div><div><br></div><div><b>Supplemental Material S3. </b>Estimated pairwise differences for F2 transition extent (Hz) from the final model.</div><div><br></div><div>Knowles, T., Adams, S., Abeyesekera, A., Mancinelli, C., Gilmore, G., & Jog, M. (2018). Deep brain stimulation of the subthalamic nucleus parameter optimization for vowel acoustics and speech intelligibility in Parkinson’s disease. <i>Journal of Speech, Language, and Hearing Research, 61, </i>510–524<i>.</i> https://doi.org/10.1044/2017_JSLHR-S-17-0157</div>